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Literature summary extracted from

  • Andersson, U.; Yang, Y.Z.; Bjorkhem, I.; Einarsson, C.; Eggertsen, G.; Gafvels, M.
    Thyroid hormone suppresses hepatic sterol 12alpha-hydroxylase (CYP8B1) activity and messenger ribonucleic acid in rat liver: failure to define known thyroid hormone response elements in the gene (1999), Biochim. Biophys. Acta, 1438, 167-174.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.139 expression in COS-7 cells Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.139 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.139 additional information Rattus norvegicus the enzyme is involved in bile acid synthesis, critical importance for the composition of bile acids formed in the liver, regulated by thyroid hormone at the mRNA level ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.139 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.139 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.139 additional information the enzyme is involved in bile acid synthesis, critical importance for the composition of bile acids formed in the liver, regulated by thyroid hormone at the mRNA level Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.139 12alpha-hydroxylase CYP8B1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.139 cytochrome P-450
-
 Rattus norvegicus